What is CBD?
~ By RaSheMa
CBD what is it? Why? and What does it do?
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You hear the buzz, and are seeing all the jazz, but what is it and what does it do you wonder. Maybe your friend recommended it and said it helped with a specific ailment like joint pain, knee pain, migraines, maybe you keep seeing ads and business popping up with it, maybe your favorite coffee shop offers it as an add in to your coffee, Or maybe your doctor recommended it. Either way it came about here we are!
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Cbd is short for cannabidol it is a naturally occurring constitute of the cannabis plant. It is 1 of at least 113 cannabinoids identified in the hemp plant. CBD has been found to interact with a variety of different biological targets, including cannabinoid receptors and other neurotransmitter receptors in the body.
Fact:
(1) “CBD products that don’t contain THC fall outside the scope of the U.S. Drug Enforcement Agency’s (DEA) Controlled Substances Act, which means CBD products are legal to sell and consume as long as they don’t have THC. That’s likely one of the reasons why CBD products, including CBD oil, are becoming more socially acceptable and increasingly popular. In 2016, Forbes reported that CBD products are expected to be a $2.2 billion industry by 2020.” (1)
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We pulled studies and information from the NCBI website. We did this because we know these are studies we can trust. If you don’t know what the NCBI website is you can click the reference number ( 2) below to learn more. They described themself as the following.
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“NCBI is The National Center for Biotechnology Information (NCBI) is part of the United States National Library of Medicine (NLM), a branch of the National Institutes of Health (NIH).National Center for Biotechnology Information
AbbreviationNCBI
Founded1988; 30 years ago
HeadquartersBethesda, Maryland, U.S.
Coordinates38.995872°N 77.098811°W
Websitewww.ncbi.nlm.nih.govThe NCBI houses a series of databases relevant to biotechnology and biomedicine and is an important resource for bioinformatics tools and services. Major databases include GenBank for DNA sequences and PubMed, a bibliographic database for the biomedical literature. Other databases include the NCBI Epigenomics database. All these databases are available online through the Entrez search engine. (2)
Here are a few studies that have been posted by NCIB on the use of cannabis.
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“Cannabis as Novel anti inflammatory” studies can be found here: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC556
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Please note the ncbi studies concluded Cannabinoids, the active components of Cannabis sativa, and endogenous cannabinoids mediate their effects through
- activation of specific cannabinoid receptors known as cannabinoid receptor 1 and 2 (CB1 and CB2).
- The cannabinoid system has been shown both in vivo and in vitro to be involved in regulating the immune system through its immunomodulatory properties.
- Cannabinoids suppress inflammatory response and subsequently attenuate disease symptoms. This property of cannabinoids is mediated through multiple pathways such as induction of apoptosis in activated immune cells, suppression of cytokines and chemokines at inflammatory sites and upregulation of FoxP3+ regulatory T cells.
- Cannabinoids have been tested in several activation of specific cannabinoid receptors known as cannabinoid receptor 1 and 2 (CB1 and CB2).
- The cannabinoid system has been shown both in vivo and in vitro to be involved in regulating the immune system through its immunomodulatory properties.
- Cannabinoids suppress inflammatory response and subsequently attenuate disease symptoms. This property of cannabinoids is mediated through multiple pathways such as induction of apoptosis in activated immune cells, suppression of cytokines and chemokines at inflammatory sites and upregulation of FoxP3+ regulatory T cells.
- Cannabinoids have been tested in several experimental models of autoimmune disorders such as multiple sclerosis, rheumatoid arthritis, colitis and hepatitis and have been shown to protect the host from the pathogenesis through induction of multiple anti-inflammatory pathways.
- Cannabinoids may also be beneficial in certain types of cancers that are triggered by chronic inflammation. In such instances, cannabinoids can either directly inhibit tumor growth or suppress inflammation and tumor angiogenesis.
- https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2828614/
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“Canabidiol as a potential treatment for anxiety disorder” Preclinical evidence conclusively demonstrates CBD’s efficacy in reducing anxiety behaviors relevant to multiple disorders, including PTSD, GAD, PD, OCD, and SAD, with a notable lack of anxiogenic effects. CBD’s anxiolytic actions appear to depend upon CB1Rs and 5-HT1ARs in several brain regions; however, investigation of additional receptor actions may reveal further mechanisms. Human experimental findings support preclinical findings, and also suggest a lack of anxiogenic effects, minimal sedative effects, and an excellent safety profile. Current preclinical and human findings mostly involve acute CBD dosing in healthy subjects, so further studies are required to establish whether chronic dosing of CBD has similar effects in relevant clinical populations. Overall, this review emphasizes the potential value and need for further study of CBD in the treatment of anxiety disorders. (3)
Cannabinoids in the management of difficult to treat pain studies can be read here https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2503660/
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More information and studies specifically on the safety and side effects can be read here at the ncbi website: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5569602/
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Healthline posted a great article with sited studies on how CBD can be used for pain, cancer, anxiety, acne, Heart health diabetes and more! This article and cited studies can be found in reference (5)
So after looking at a few studies, we begin to find many benefits when it comes to CBD. People have reported success in sports recovery, pain, anxiety, fibromyalgia, stress, arthritis and so much more!
The Web MD website stated “There also is some indication that CBD might harm the liver. About 10 percent of people taking CBD in studies had increases in liver enzymes, which would indicate possible liver damage, Welty said.” (4)
Interestingly enough the studies where not posted to back this up, there we’re no cited references and the NCBI studies directly counteract this claim! With all this said to be wary of the information you take in, be sure it truly is from a reputable source with cited studies! Please have a look at some other articles such as Synthetic CBD and FDA regulations or how does CBD work in the body!
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* These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
Refrences 1 https://www.livescience.com/63452-what-is-cannabis-oil.html2https://en.m.wikipedia.org/wiki/National_Center_for_Biotechnology_Information3https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4604171/
4https://www.webmd.com/pain-management/news/20180507/cbd-oil-all-the-rage-but-is-it-safe-effective#1
(5) https://www.healthline.com/nutrition/cbd-oil-benefits#section7
